Background: The aim of this study was to explore the prognostic factors and establish a nomogram to predict the\nlong-term survival of gastric cancer patients.\nMethods: The clinicopathological data of 421 gastric cancer patients, who were treated with radical D2\nlymphadenectomy by the same surgical team between January 2009 and March 2017, were collected. The analysis\nof long-term survival was performed using Cox regression analysis. Based on the multivariate analysis results, a\nprognostic nomogram was formulated to predict the 5-year survival rate probability.\nResults: In the present study, the total overall 3-year and 5-year survival rates were 58.7 and 45.8%, respectively.\nThe results of the univariate Cox regression analysis revealed that tumor staging, tumor location, Borrmann type,\nthe number of lymph nodes dissected, the number of lymph node metastases, positive lymph nodes ratio,\nlymphocyte count, serum albumin, CEA, CA153, CA199, BMI, tumor size, nerve invasion, and vascular invasion were\nprognostic factors for gastric cancer (all, P < 0.05). However, merely tumor staging, tumor location, positive lymph\nnode ratio, CA199, BMI, tumor size, nerve invasion, and vascular invasion were independent risk factors, based on\nthe results of the multivariate Cox regression analysis (all, P < 0.05). The nomogram based on eight independent\nprognostic factors revealed a well-degree of differentiation with a concordance index of 0.76 (95% CI: 0.72â??0.79,\nP < 0.001), which was better than the AJCC-7 staging system (concordance index = 0.68).\nConclusion: The present study established a nomogram based on eight independent prognostic factors to predict\nlong-term survival in gastric cancer patients. The nomogram would be beneficial for more accurately predicting the\nprognosis of gastric cancer, and provide important basis for making individualized treatment plans following\nsurgery.
Loading....